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Tampilan Lengkap Majalah
id_buku
12244
judul
Efek antiproliferatif pentagamavunon-0 terhadap sel kanker payudara T47D
nama_majalah
Jurnal Kedokteran YARSI
volume
14
tahun
2006
nomor
1
halaman
011 - 015
pengarang
Meiyanto, Edy ; Supardjan ; Da'i, Muhammad ; Agustina, Dewi
abstrak
Breast cancer is the most common cancer occurring in women. Pentagamavunon-0 (2,5-bis-(4'-hidroxy-3' -methony)-benzilidine- cyclopentanone. PGV-0), is a curcumin (1,7-bis-(4'-hidroxy--3' methoxy phenyl)-1,6-heptadiene-3,5dione), analogue that has been proven for its anticancer activity. The aim of this study is to examine the anti proliferative effect of PGV-0 on breast cancer cell line, T47D, tested by MTT method. Inhibition ability of this compound was evaluated by BrdL1 incorporation assay. The resuld showed that PGV-0 was more potential as cytotocix agent compared to curcumin by IC-50 11 JM respectively. PGV-0 inhibited the cell growth started at 5 jM, and curcumi started at 10jM. The inhibition of S-phase progression. It was concluted that PGV-0 was more potent then curcumin as antiproliferative agent on breast cancer cell line.
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